Hematological Values in Young Adults

Hematological determine in Young AdultsA field of force on complete rake cell appear in schoolboyish healthy Medical individuals digestBackground complete melodic phrase cell aim is a frequently use laboratory sample for the diagnosis of several diseases, in health examination and preoperative evaluation. The value of hematological parameters atomic number 18 affected by a number of factors even in apparently healthy population. latterly it was reported that white blood cell come and blood platelet comes are associated with cardiovascular diseases. It is of interest to note that the premenopausal women fuddle a reject incidence of cardiovascular disease than men possibly due to young-bearing(prenominal) sex hormonal picture on platelet functions. so this get h of age(predicate) of has been conducted in order to determine whatsoever sex sport effect on hematological parameters in apparently healthy male and pistillate young adult subjects.Aims and objectives The aim of this study is to measure the various hematological value in the young adult male and womanish subjects and because to compare their results.Methods 80 young adult students between 17 to 20 historic period of age gathering have participated in this study voluntarily. aft(prenominal) existence informed blood samples of subjects had been taken in morning. Haematological parameters were analysed by Sysmex KX -21 automated hematology analyzer. The haematological changes in between male and female subjects were analyzed by Students paired t test respectively.Result It shows that difference between the levels of first derivative leukocyte cell count on, Hemoglobin and thrombocyte count of the two studied group is statistically hearty (p draw words male, womanish, Blood cell, Hemoglobin, Leucocyte, PlateletIntroductionStudy of hematological parameters same(p) complete blood cell count is a frequently use laboratory test performed to support the diagnosis of several diseases. It is also used in periodic health examination and preoperative evaluation. The values of hematological parameters are affected by a number of factors even in apparently healthy population. These include age, sex, body builds, and nutritional, env squeezemental and social factors with heathenish backgrounds.1 It has been shown in several studies that virtually of the hematological parameters exhibit considerable variation in different period of life. At birth the total Hb level, red blood cell count, PCV are shown to be higher than at any some other period of life.2,3 The levels of these parameters then decrease during the next few months after birth, some more steeply than others, with cells becoming hypo chromic with the development of physiological iron deficiency anemia.4 The Hb content and RBC count then step by step rise and approaches near to the adult levels by the age of puberty.5 In world(a) the male hematological levels are higher than the adult female lev els.6 However, aver et al (1985)7 reported that total white blood corpuscle Platelet counts are importantly higher in adolescent female than adolescent male subjects of 14-16 years of age. Recently it was also reported that white blood cell count and platelet counts are associated with cardiovascular diseases. Total WBC and certain subtype counts in young adulthood are importantly associated with the presence of coronary arteria calcification (CAC) 15 or 20 years later in early(a) mettle age. This suggests possible involvement of WBC in initiation or early development of atherosclerosis at later age of life.8 Therefore, study on WBC at an early adulthood is important.TestMaleFemaleP-valueRBC4.760.384.590.290.075Hb (g/dl)13.581.0512.671.100.005*HCT(%)41.964.5139.922.700.064MCH(pg)28.671.9027.601.610.041*MCHC(g/dl)32.792.2431.700.930.033RDW (fl)46.314.5544.042.670.036*Materials and methods40 healthy females average 20.75 2.23 years old and 40 healthy males , on average 20.83 0 .96 years old a total of 80 people apparently healthy have participated in this study on a voluntary basis. The subjects was excluded from the study, if they Suffer from any hematological, endocrinological, gynecological, cardiovascular, respiratory and nervous disorders and evidence of infection at the time of take in or Subject had history of Blood transfusion or present in last 3 months. The protocol has been explained to the subjects. 2 ml of venous blood sample was drawn between 9 a.m to 12 noon from anticubital vein under aseptic precautions in to a vial containing of 10% potassium EDTA to turn away diurnal variations. The sample was analysed immediately within 1-2 hrs, to avoid any variations due to storage. Hematological parameters such as red blood cell count (CBC), haemoglobin (HBG), hematocrit value (HCT), mean(a) corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), erythrocyte distribution width (RDW), leukocyte count (TL C), Differencial cell count, platelet count (PLT) were analyzed with Sysmex-kx-21 brand blood cell counter wrench in central laboratory of Dhiraj hospital Piparia from July 2012 to Oct 2012. SPSS program has been used in assessment of data. Results have been decided on basis of Mean and commonplace Deviation. t test was applied in independent groups to compare them. 0.05 values were accepted as significant.Results tabulate 1 Erythrocyte Parameters of Male (n=40) and Females (n=40)Table 2 Leukocyte Platelet count of Male (n=40) and Females (n=40)TestMaleFemaleP-valueTotal WBC count7.48 1.857.02 2.000.418Differential Neutrophil count65.33 7.8356.70 13.590.010*Differential Lymphocyte count29.90 9.7235.80 9.740.041*Differential Monocyte count5.85 2.167.49 1.100.002*Total Platelet count218.79 29.96252.54 37.840.001*DiscussionIn our study Erythrocyte parameters like Hemoglobin, MCH and MCHC have been build to be higher in males, total WBC count with neutrophil count also highe r in male subjects. Whenever lymphocyte count, monocyte count and Platelet were higher in female subject. EL- Hazmi and Warsy (2001) studied Saudi Children with ages ranging from 1-15 years. The RBC determine did not Show a Significant Changes in the 1 to 13 year Old but rope slightly beyond this age. No Significant differences were observed in red cell count in the male and female children. White blood cell little by little decreased 2 years onwards, While Hemoglobin and hematocrit levels change magnitude significantly from 2 to 15 years. The same author reported WBC Count 10.9 3.8 x 1012/L , 6.9 3.1 x 10 9/L in one year olds , 9-11 years 12-15 years age group respectively.9 Ghafouri et al (1987) reported that total aim of hemoglobin was 13.7 1.0 g/dl And 13.5 1.0 g/dl, respectively in male female children, with ages ranging from 12-15 years. Hemoglobin Level was Lowest in the two-year olds, and then gradually increased up to 15 years of age in both boys girls. The diffe rences of Boys Girls Level was significant after 14 years of age, The male values were Higher than the female values.10 Usman k et al (2007) studied 302 healthy volunteers, both male and female, ages localize between 20-45 years. They found, in males, the mean Hb concentration of 13.04 g/dl. Was significantly higher than females value of 11.63 g/dl. The RBC Count of 5.3 x1012/L in males was significantly higher than the corresponding Values of 4 x10 12/L in females. On the other hand The mean WBC Count of 8.25 x 109/L in males was lower than the mean values of 8.42 x109/L in females. Similarly the Values for platelet count of 255 x109/L in males were also Significantly lower than corresponding values of 279 x 10 9/L in females .11 Khanduri et al (2005) reported platelet counts in 25 males 25 females normal adult Indians the range being 111-338 (x 10 9 /L) and 137-337 ( x 10 9/L) respectively.12 Earlier Bain (1985) reported the mean platelet counts which were 288 and 262 x 109/L i n Caucasian females and males respectively. 13 Casimir et al (2010) reported that gender influences clinical presentation and markers in inflammatory diseases, in many chronic condititions frequency of complications is greater in females with the increase proceeds of inflammatory markers like CRP (C reactive protein). Neutrophil count and ESR .14 Although numerous studies have been undertaken to examine the effects of Gender and various factor on differential blood counts but results have often been inconclusive and foreign (Makinoda et al,1996)15ConclusionAlthough blood cells of both groups are within the annex range, their being low or high in numbers is based on various factor like age, sex, body build, and nutritional, environmental and social factors with cultural backgrounds. For clearance similar type of studies with multi subject and multi repetition are needed.ReferencesMohson AF, Hazmi EL, Warsy As. sane reference values for hematological parameters, red cell indice s, HbA2 and HbF from early childishness through adolescence in Saudis. AS M 2001 21 165-169.Matoth Y, Zaizon R, Varsano I. Postnatal changes in some red cell parameters. Acta Paediatr Scand 1971 60 371.Marwaha N, Marwaha RK, Narang A, Thusu K,Garewal G, Bhakod ON, Routine hematological values in term newborns. 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Haematological reference values assessed from birth to adolescent in Saudi subjects in the stadium of Jeddah. Saudi Med J 1987 8 575-82.Usman K, Syed ZA, Rao AA. References range values of hematological parameters in healthy Pakistani adults. Pak J Physiol 2007 19-22.Khanduri U, Sharma A and Joshi A. occult cobalamin and folic acid deficiency in Indians. The national medical journal of india, 2005 18(4) 182-183.Bain BJ Platelet count and platelet size in males and females. Scand J Haematol 1985 35 77-9.Casimir G, Muller S, Hanssens L, Zilberg K, Duchateau J. Gender differences in inflammatory markers in infancy. Shock, 2010, 33(3) 258-262.Makinoda S, Mikuni M, Sogame M, Kobamastsu Y, Yamada H, Yamamoto R, F ujimoto S, FUruta I. Erythropoietin, granulocyte colony stimulating factor, interlukin-1 beta and interleukin-6 during the catamenial cycle. Int J Gynecol Obstet 1996 55 265-71.